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Sapper: Call SNV and allele-specific binding events from a single ChIP-seq dataset

Introduction

We present a novel algorithm, called Sapper, to infer variation and allele-specific events at regulatory elements directly from single ChIP-Seq assay without the need for the costly whole genome sequencing. We use local DNA assembly in peak region to conquer the reference mapping bias, and infer SNV and allele-specific binding behavior based on statistical model simultaneously.

Install & Usage

https://github.com/LiuLabUB/SAPPER/tree/master/src

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